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Is Pantothenic Acid a Magic Cure for Acne?

In 2014 a study was published that reported success treating acne using a high dose of pantothenic acid, also known as Vitamin B5.   As you can imagine, as a Naturopathic Doctor specializing in acne I was immediately all over this study.

Could there really be a magic pill for acne?  It seemed too good to be true.  After digging into the study, trying the protocol with my patients and investigating pantothenic acid a bit more I decided to drop pantothenic acid from my acne protocol.  Here’s why.

The Study

One small study is not usually conclusive, and this holds true for the research paper published in 2014 suggesting that pantothenic acid could reduce acne lesions.  More research needs to be done – but it did spark so many questions and interesting insights!

The study was conducted with 40 patients (mostly women) over the course of 12 weeks.  Patients were given 2.2 grams of pantothenic acid daily, and at the end of 12 weeks the number of blemishes on the skin was compared with their baseline (the number of blemishes on their face at the beginning of the study).

The chart of results is shown below:

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The blue bar represents the number of acne lesions at baseline and week 12 in the patients taking a pantothenic acid supplement.  The red bar represents the number of acne lesions at baseline and week 12 in the patients taking a placebo, which means participants THINK they are taking an active medication, but they are not.

As you can see, even though there are some significant results with pantothenic acid, there is also a tremendous result with the placebo – when the study subjects just THINK that they are taking a remedy.  This is called the placebo effect, and it demonstrates that our mind is incredibly powerful – when we think we are taking a remedy we will experience healing.

My question is – even though the study claims that pantothenic acid reduces acne lesions by 67% – how much of that improvement is actually attributed to the placebo effect?

The other interesting thing about the study is that almost all the improvement in acne was seen in non-inflammatory acne, which is blackheads and small whiteheads.  

Acne that was more inflamed, red and cystic did not see the same improvement as milder acne.  This suggests that pantothenic acid is more effective against mild acne.

What is Pantothenic Acid?

Pantothenic acid, also known as vitamin B5, is converted in the body to Coenzyme A (CoA).  The  functions of CoA include converting fats, proteins and carbohydrates into energy, regulating skin function and cortisol production.

These functions are especially important in acne pathogenesis because pantothenic acid can affect fat and oil production in the skin, regulate keratinocyte proliferation, and moderate our stress response – all factors in acne pathogenesis.

For years we thought that pantothenic acid was delivered to our body solely through our diet.  Many food sources contain pantothenic acid, and it is highly bioavailable and absorbable.  It is found in eggs, meat, poultry, lentils, broccoli, cabbage, potatoes, while grains, nuts, and beans – basically most of the foods that are included in a healthy diet! 

Why does pantothenic acid help some mild cases of acne?

If you eat a diet composed mainly of processed foods, you may not get the amount of pantothenic acid required to keep your body healthy.  A daily diet of processed cereals, peanut butter sandwiches, sodas and pizza is void in all nutrients (not just vitamin B5)! 

But it turns out that a pantothenic acid deficiency has less to do with diet, and more to do with the microbiome.

More recent research has revealed that B vitamins are not only acquired through our food but also produced by our microbiome.  In fact, studies are suggesting our most important source of pantothenic acid and other B vitamins is actually from our intestinal microbiome.

This means that if your gut is not healthy and balanced you could be experiencing a deficiency in pantothenic acid, regardless of how much you eat in your diet.  And this is why high-dose supplementation of pantothenic acid is able to positively affect mild acne in some people.  It is thought that a high dose is able to flood the pantothenic acid receptors temporarily to produce CoA in the body.  As discussed before, CoA helps regulate lipid metabolism, keratinocyte turnover and the stress response.

But think about it – in our diet we need approximately 5mg of pantothenic acid per day.  It takes 2.2 grams of synthetic pantothenic acid daily to trigger the response that should be happening naturally in our body.   As a Naturopathic Doctor, I want deeper healing for my patients.

Why do I not recommend high-dose pantothenic acid for acne.

1. As a Naturopathic Doctor I am always investigating the underlying cause of a condition so I can solve the problem for good. Taking high dose pantothenic acid daily does not solve the root issue.  It masks an underlying problem.  Once you stop taking the supplement, the acne will come back.

2. One of the root problems of acne is an imbalanced microbiome. This is what leads to a deficiency of endogenous pantothenic acid in the body, which can negatively affect lipid metabolism and epidermal regulation which can lead to acne.  Instead of targeting the pantothenic acid deficiency by flooding the body’s receptors with synthetic pantothenic acid, my goal is to re-regulate its natural production in the body.

3. When the microbiome is balanced, not only will the body produce adequate amounts of pantothenic acid, but many other imbalances in the body will also improve. Digestion will start to work optimally, inflammation will decline and hormones will start to naturally balance.  Supplemental pantothenic acid will not affect any of the other imbalances caused by an unhealthy microbiome.

4. Supplemental pantothenic acid only affects mild acne, and often my patient population have moderate to severe acne – which means that deeper and more complete healing is required.

5. High dose pantothenic acid works for some people, and not for others. I like to eliminate guesswork as much as possible which is why I choose not to use it in my patient protocols.

The Bottom Line

Supplemental pantothenic acid is a band-aid solution for a much more serious problem – an unbalanced microbiome.  In my practice I choose to solve the underlying issues and get rid of acne for good.

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Muoma Valentine
Updated 1 Month ago · 0 Likes · 0 Comments

AN UNPALATABLE PANDEMIC HITS HUMANITY 

BY MUOMA VALENTINE CHIBUEZE 

An unpalatable pandemic hits humanity,

Causing pandemonium

Ravaging nations of the world

Has succeeded in holding us apart

in the name of social distance

Isolation, quarantine, lockdown, sickness, fear, panic, hunger has become the order of the day


Those who are sick now fear going to the hospital

For fear of being suspected of COVID-19

Even those with the virus are scared of opening up

For fear of being segregated

Thereby infecting others

Increasing the spread the virus.


The pandemic has become a throb in our neck

Its tremulous beats wake trenchant

Its stings becoming catastrophic to the well-being of the nation

The number of cases keep raising daily and has become a plethora


The social media has become agents of adulterated news

Bringing forth absurd means of combating the virus

Propagating outrageous number of cases

Creating panic, fear and chaos in the land.


Observing safety tips is the only panacea to contending the virus

Anything contrary exacerbates the pandemic

Continuous public health enlightenment Should be accessible to everyone.


Corrections of fallacies on the spread of the virus 

Is our collective responsibility

Looking out for one another is imperative

With all these measures on ground

We can successfully overcome this unpalatable pandemic.


ABOUT THE POET

Muoma Valentine Chibueze is a poet, essayist and motivational speaker. He is currently a student of Nnamdi Azikiwe University, Awka.

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Teo Han Siang
Updated 1 Month ago · 0 Likes · 0 Comments

Financial reports are critical since they contain significant information about the financial health of a business. These reports allow business owners to make an informed decision as they highlight which companies’ areas offer the best return-on-investment. Unless exempted, companies in Singapore are mandated to file their financial reports or statements with ACRA. The reports must abide by the Singapore Financial Reporting Standards or SFRS that the Accounting Standards Council issued.

Other benefits of financial reporting include:

  • Enhanced debt management: Regardless of the business sector, debt can cripple the company’s development all the same. Financial reports allow companies to track their current assets divided by their current liabilities on their balance to help gauge their liquidity and handle their debts accordingly.
  • Identification of trend: Financial statements allow business owners to spot trends, both past and the present, which empower them to overcome potential weaknesses while assisting them in making improvements that will be beneficial to their business’s overall health.
  • Real-time tracking: By getting access to centralised, real-time insights, business owners would be able to make informed business decisions swiftly, hence, preventing any possible hurdles while keeping their financial fluidity all the time.
  • Liabilities management: Proper liabilities management is a vital part of the ongoing financial health of the company. Examples of integral liabilities include business loans and credit cards. The financial statements allow business owners to determine whether they need to decrease existing liabilities before making an official business loan application.

Business entities exempted from the financial report filing are as follows:

  • Partnerships, including limited partnerships
  • Sole proprietorships
  • Solvent EPCs or Exempt Private Companies. While solvent EPCs are exempted, they are encouraged to file their financial statements.
  • Dormant unlisted companies, which are dormant from their establishment’s time or since the end of the past financial year.

To ensure accurate and legally compliant financial reporting, business owners should seek assistance from reputable Singapore accounting services. When selecting accounting services in Singapore, be sure to consider factors like the agency’s credibility, reliability, industry expertise, pricing model, and extra services.

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Posted 1 Year ago · 2 Likes · 0 Comments

There are several motivators  for engaging in different bodybuilding exercises. The sport of bodybuilding is one that has inspired  a lot of people. Many will hit the gym to achieve the desirable type of body for competitions like the famous Mr. Olympia. There are so many bodybuilders and actors out there who have inspired people all around the world  to visit the gym and engage in various workouts.

Getting that type of body is not that easy because you have to put in a lot of  work. Apart from exercising, you can also use of supplements that will speed up the  process of acquiring the desired body mass. You can check them out online, for example, Samento, which is cheap and readily available.

One type of exercise common among many bodybuilders is the deadlift. It is a weight training workout which involves lifting a barbell  loaded with extra weights slowly from the ground to your hip level. This is a good exercise because it helps to stimulate both upper and lower parts of your body. There are times when you may get injured or need a change from deadlifting , so here are some of the best alternatives:

Block Pull

This  is one of the best alternatives to deadlifting that you can try. Commonly referred to as a rack pull, you must first  load their bar with weights. They should be at your knee level. Also, keep the bar at a slight distance from your body. Make sure your back is straight as you lift the bar, assuming a position that will allow you to do so. If you’re interested in taking your training further, you could  find a personal trainer who could help you to train as required and avoid injuries.

One-Leg Deadlift

This  is another ideal alternative to the deadlift. This type of exercise provides your body with the perfect body balance. It is quite similar to the regular deadlift, the only difference being that you have to do it with one of your legs. You can try out both sides to get quality results. Make sure your back is straight throughout the exercise.

Reverse Hyper

A  great exercise, a few sets of these  can help improve your hip movements. The reverse exercise can also help build strength in the upper parts of your body. It can be done on a flat bench. All you need to do is to lay down flat on one side of the bench with your face facing down and your legs on the floor. Raise your legs and hips slowly above the floor, before lowering them back slowly.

One Arm Deadlift

This is another excellent exercise which can be done using a dumbbell. It helps stimulate the upper part of your body. Place a dumbbell on the outside of one of one of your feet. Gently bend, slowly, with your back straight, and lift the dumbbell carefully . You can do this  for both arms and repeat several times if you feel capable.


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